e-PTFE의 산소 및 질소 플라즈마 표면처리에 따른 조골모세포의 증식효과
Effect of oxygen and nitrogen plasma surface modification on preosteoblast cell proliferation on e-polytetrafluoroethylene (e-PTFE)
정승곤, 박홍주, 오희균, 문대선, 국민석,
소속 상세정보
정승곤 ( Jung Seung-Gon ) - 전남대학교 치의학전문대학원 구강악안면외과학교실
박홍주 ( Park Hong-Ju ) - 전남대학교 치의학전문대학원 구강악안면외과학교실
오희균 ( Oh Hee-Kyun ) - 전남대학교 치의학전문대학원 구강악안면외과학교실
문대선 ( Moon Dae-Seon ) - KJ 메디텍
국민석 ( Kook Min-Suk ) - 전남대학교 치의학전문대학원 구강악안면외과학교실
KMID : 1035320150420010045
Abstract
e-Polytetrafluoroethylene (e-PTFE) is a commonly used medical polymer due to its biological stability and excellent mechanical properties such as high hardness and wear resistance. However, the superhydrophobic surface and lack of functional groups to interact with the cellular environment have severely limited its applications in bone or cartilage replacements. In this study, e-PTFE surface was modified by oxygen (O₂) or nitrogen (N2) RF plasma treatment in order to improving the hydrophilic property and preosteoblast cell proliferation. After the plasma treatment, e-PTFE surface was characterized by using a contact angle measurement, atomic force microscopy, and scanning electron microscopy. The contact angle of e-PTFE surface was significantly decreased and surface morphology did not changed. The MC3T3-E1 cell proliferation was evaluated by MTT assay. The N₂ or O₂ plasma- treated e-PTFE groups showed the higher cell proliferation than untreated group. In conclusion, the N₂ or O₂ gas plasma surface modification used in this study indicates the potential technique as a promising e-PTFE biomedical application.
키워드
e-Polytetrafluoroethylene; Plasma surface modification; Contact angle; Preosteoblast cell proliferation
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